Agonizing Integrin Antagonists?

Agonizing Hedgehog

program teaches us something about the biology of the process that it attempts to modulate. The paper by Maria Frank-Kamenetsky and colleagues in this issue of the Journal of Biology [1] presents a compelling example of how the search for therapeutics can provide powerful experimental tools and insights into fundamental biology, blurring the distinction between applied and basic research. By ch...

NMR Spectroscopy for Studying Integrin Antagonists

Impulsive Actions and Agonizing Decisions

Rather than having precise preferences consistent with a single utility function over commodity bundles, individuals are assumed to have imprecise preferences with a set of possible utility functions, one of which is the true one. When attention is devoted to the task the set of utility functions contracts, making preferences more precise. This increases the individual’s willingness to pay for ...

Discovery of VLA-4 (α4β1-integrin) allosteric antagonists

ANTAGONISTS* Alexandre Chigaev, Yang Wu, D. Bart Williams, Yelena Smagley, and Larry A. Sklar From the Department of Pathology and Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 Running head: VLA-4 allosteric antagonists Address correspondence to: Alexandre Chigaev, PhD, or Larry A. Sklar, PhD, MSC08 4630, 915 Camino de Salud, Albuquerque, NM 87131...

LazySVD: Even Faster SVD Decomposition Yet Without Agonizing Pain

We study k-SVD that is to obtain the first k singular vectors of a matrix A. Recently, a few breakthroughs have been discovered on k-SVD: Musco and Musco [19] proved the first gap-free convergence result using the block Krylov method, Shamir [21] discovered the first variance-reduction stochastic method, and Bhojanapalli et al. [7] provided the fastestO(nnz(A)+ poly(1/ε))-time algorithm using a...